高等有机化学-结构与机理(第五版)_PDF下载[121MB-百度云]卡雷(Carey.F.A.)

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《高等有机化学:结构与机理》(第5版)自从1997年面世以来，《高等有机化学》作为学科首选教材的地位一直没有动摇过，广泛地覆盖了有机化合物的结构、反应活性及合成。她的第五版相对2001年出版的第四版进行了大幅度的修订，更新了学科发展的相关资料，内容组织更加清晰明朗，特别是计算化学部分。Part A从化合物结构和立体化学基础概念讲起，涉及有机化学反应热力学和动力学的方方面面。主要反应类型涵盖亲核取代反应、加成反应、碳负离子和羰基化学反应、芳环取代反应、周环反应、自由基反应和光化学反应。每章后附有习题精选及解答习题的推荐参考文献。

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本书特色

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《高等有机化学:结构与机理》(第5版)可供有机化学、药物化学和生物化学等专业的高年级本科生、研究生以及相关领域的科研人员参考。

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PrefaceAcknowledgment and Personal StatementIntroductionChapter 1 Chemical Bonding and Molecular StructureIntroduction1.1 Description of Molecular Structure Using Valence Bond Concepts1.1.1 Hybridization1.1.2 The Origin of Electron-Electron Repulsion1.1.3 Electronegativity and Polarity1.1.4 Electronegativity Equalization1.1.5 Differential Electronegativity of Carbon Atoms 1.1.6 Polarizability, Hardness, and Softness1.1.7 Resonance and Conjugation1.1.8 Hyperconjugation1.1.9 Covalent and van der Waals Radii of Atoms1.2 Molecular Orbital Theory and Methods1.2.1 The Hiickel MO Method1.2.2 Semiempirical MO Methods1.2.3 Ab Initio Methods1.2.4 Pictorial Representation of MOs for Molecules1.2.5 Qualitative Application of MO Theory to Reactivity: Perturbational MO Theory and Frontier Orbitals1.2.6 Numerical Application of MO Theory1.3 Electron Density Functionals1.4 Representation of Electron Density Distribution1.4.1 Mulliken Population Analysis1.4.2 Natural Bond Orbitals and Natural Population Analysis1.4.3 Atoms in Molecules1.4.4 Comparison and Interpretation of Atomic Charge Calculations1.4.5 Electrostatic Potential Surfaces1.4.6 Relationships between Electron Density and Bond OrderTopic 1.1 The Origin of the Rotational (Torsional) Barrier in Ethane and Other Small MoleculesTopic 1.2 Heteroatom Hyperconjugation (Anomeric Effect) in Acyclic MoleculesTopic 1.3 Bonding in Cyclopropane and Other Small Ring CompoundsTopic 1.4 Representation of Electron Density by the Laplacian FunctionTopic 1.5 Application of Density Functional Theory to Chemical Properties and ReactivityT 1.5.1 DFT Formulation of Chemical Potential, Electronegativity, Hardness and Softness,and Covalent and van der Waal RadiiT 1.5.2 DFT Formulation of Reactivity——The Fukui Function ..T 1.5.3 DFT Concepts of Substituent Groups EffectsGeneral ReferencesProblemsChapter 2 Stereoehemistry, Conformation, and Stereoselectivity.. “Introduction2.1 Configuration2.1.1 Configuration at Double Bonds2.1.2 Configuration of Cyclic Compounds2.1.3 Configuration at Tetrahedral Atoms2.1.4 Molecules with Multiple Stereogenic Centers2.1.5 Other Types of Stereogenic Centers2.1.6 The Relationship between Chirality and Symmetry2.1.7 Configuration at Prochiral Centers2.1.8 Resolution——The Separation of Enantiomers2.2 Conformation2.2.1 Conformation of Acyclic Compounds2.2.2 Conformations of Cyclohexane Derivatives2.2.3 Conformations of Carbocyclic Rings of Other Sizes2.3 Molecular Mechanics2.4 Stereoselective and Stereospecific Reactions2.4.1 Examples of Stereoselective Reactions2.4.2 Examples of Stereospecific Reactions2.5 Enantioselective Reactions2.5.1 Enantioselective Hydrogenation2.5.2 Enantioselective Reduction of Ketones2.5.3 Enantioselective Epoxidation of Allylic Alcohols2.5.4 Enantioselective Dihydroxylation of Alkenes2.6 Double Stereodifferentiation: Reinforcing and Competing StereoselectivityChapter 3 Strucral Effects on Stability and ReactivityChapter 4 Nucleophilic SubstitutionChapter 5 Polar Addition and Elimination ReactionsChapter 6 Carbanions and Other Carbon NucleophilesChapter 7 Addition,Condensation and Substitution Reactions of Carbonyl CompoundsChapter 8 AromatictityChapter 9 Aromatic SubstitutionChapter 10 Concerted Pericyclic ReactionsChapter 11 Free Radical ReactionsChapter 12 PhotochemistryReferences to ProblemsIndex